https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34315 Wed 27 Feb 2019 12:25:36 AEDT ]]> Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2781 Wed 24 Jul 2013 22:53:08 AEST ]]> The role of Ca²⁺-calmodulin stimulated protein kinase II in ischaemic stroke - a potential target for neuroprotective therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34507 2+ -calmodulin stimulated protein kinase II (CaMKII) is a major mediator of ischaemia-induced cell death and suggest that CaMKII would be a good target for neuroprotective therapies in acute treatment of stroke. However, as CaMKII regulates many cellular processes in many tissues any clinical treatment involving the inhibition of CaMKII would need to be able to specifically target the functions of ischaemia-activated CaMKII. In this review we summarise new developments in our understanding of the molecular mechanisms involved in ischaemia-induced CaMKII-mediated cell death that have identified ways in which such specificity of CaMKII inhibition after stroke could be achieved. We also review the mechanisms and phases of tissue damage in ischaemic stroke to identify where and when CaMKII-mediated mechanisms may be involved.]]> Wed 20 Mar 2019 10:25:57 AEDT ]]> Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10824 Wed 11 Apr 2018 16:58:46 AEST ]]> Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15023 Wed 11 Apr 2018 16:31:59 AEST ]]> The sustained phase of Tyrosine hydroxylase activation in vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17101 Wed 11 Apr 2018 09:35:27 AEST ]]> Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37005 Wed 05 Aug 2020 11:42:14 AEST ]]> Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33093 Wed 04 Sep 2019 09:56:33 AEST ]]> Peripheral lipopolysaccharide challenge induces long-term changes in tyrosine hydroxylase regulation in the adrenal medulla https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33092 Wed 04 Sep 2019 09:56:32 AEST ]]> Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27809 Wed 02 Mar 2022 14:24:39 AEDT ]]> Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18174 Tue 23 Jun 2015 18:29:53 AEST ]]> Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23713 max reduction and increasing the KM for the cofactor.]]> Tue 18 Oct 2016 16:59:59 AEDT ]]> Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15128 Tue 13 Aug 2024 10:05:20 AEST ]]> CaMKII kinase activity, targeting and control of cellular functions: effect of single and double phosphorylation of CaMKIIα https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16963 Thu 30 Mar 2023 15:52:22 AEDT ]]> Ischaemia- and excitotoxicity-induced CaMKII-Mediated neuronal cell death: the relative roles of CaMKII autophosphorylation at T286 and T253 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34319 2+-calmodulin stimulated protein kinase II) that initiates cell death. This study investigated the involvement of CaMKII phosphorylation at T286 and T253 in producing this persistent activation. In T286A-αCaMKII transgenic mice that lack the ability to phosphorylate αCaMKII at T286, transient occlusion of the middle cerebral artery for 90 min resulted in no significant difference in infarct size compared to normal littermate controls. Overexpression of the phospho-mimic mutant T286D-αCaMKII in differentiated neuroblastoma cell lines did not enhance excitotoxicity-induced cell death compared to overexpression of wild type αCaMKII. By contrast, overexpression of the phospho-mimic mutant T253D-αCaMKII significantly enhanced excitotoxicity-induced cell death whereas overexpression of the phospho-null mutant T253V-αCaMKII produced no enhancement. These results indicate that T286 phosphorylation does not play a significant role in ischaemia/excitotoxicity induced CaMKII-mediated cell death and suggest that T253 phosphorylation is required to produce the persistent activation of CaMKII involved in ischaemia/excitotoxicity induced cell death.]]> Thu 27 Jan 2022 15:59:30 AEDT ]]> Neonatal overfeeding increases capacity for catecholamine biosynthesis from the adrenal gland acutely and long-term in the male rat https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43297 Thu 15 Sep 2022 12:51:33 AEST ]]> αCaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13748 Sat 24 Mar 2018 10:39:18 AEDT ]]> Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8304 Sat 24 Mar 2018 08:40:32 AEDT ]]> Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7232 Sat 24 Mar 2018 08:40:26 AEDT ]]> The low affinity dopamine binding site on tyrosine hydroxylase: the role of the N-Terminus and in situ regulation of enzyme activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8116 Sat 24 Mar 2018 08:40:01 AEDT ]]> Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9423 Sat 24 Mar 2018 08:39:18 AEDT ]]> Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: isoform 2 is not phosphorylated at Ser35 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8022 Sat 24 Mar 2018 08:36:49 AEDT ]]> Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9573 Sat 24 Mar 2018 08:34:46 AEDT ]]> Tyrosine hydroxylase phosphorylation: regulation and consequences https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1891 Sat 24 Mar 2018 08:33:21 AEDT ]]> Phosphorylation of Ser¹⁹ alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser⁴⁰ https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1973 Sat 24 Mar 2018 08:33:17 AEDT ]]> Phosphorylation of Ser19 alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser40 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1318 Sat 24 Mar 2018 08:32:34 AEDT ]]> Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1880 Sat 24 Mar 2018 08:31:18 AEDT ]]> Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1185 Sat 24 Mar 2018 08:28:29 AEDT ]]> Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1174 Sat 24 Mar 2018 08:28:28 AEDT ]]> The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12480 Sat 24 Mar 2018 08:17:19 AEDT ]]> Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10760 Sat 24 Mar 2018 08:13:54 AEDT ]]> Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19054 Sat 24 Mar 2018 08:05:15 AEDT ]]> Mechanism of action of salsolinol on tyrosine hydroxylase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18322 Sat 24 Mar 2018 08:04:30 AEDT ]]> Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17102 Sat 24 Mar 2018 08:02:32 AEDT ]]> mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20866 Sat 24 Mar 2018 07:57:51 AEDT ]]> Murine dopaminergic Müller cells restore motor function in a model of Parkinson's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21373 Sat 24 Mar 2018 07:51:27 AEDT ]]> Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5208 Sat 24 Mar 2018 07:47:45 AEDT ]]> Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:214 Sat 24 Mar 2018 07:43:00 AEDT ]]> Mutational analysis of catecholamine binding in tyrosine hydroxylase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25252 Sat 24 Mar 2018 07:38:16 AEDT ]]> Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30987 Mon 20 Nov 2023 14:18:12 AEDT ]]> Tyrosine hydroxylase phosphorylation in vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36204 Mon 02 Mar 2020 13:51:01 AEDT ]]> Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24492 -1 Mn, and this correlated with an increase in TH phosphorylation at serines 40, 31 and 19. However, in the striatum at PND70, a time by which Mn levels were no longer elevated, there was a dose dependent decrease in TH protein levels, reaching significance at 20 mg kg-1 Mn, and this correlated with TH phosphorylation at Ser40 and Ser19. There was however a significant increase in phosphorylation of TH at serine 31 at 20 mg kg-1 Mn, which did not correlate with TH protein levels. Taken together our findings suggest that neonatal Mn exposure can have both short-term and long-term effects on the regulation of TH in the striatal dopaminergic system.]]> Fri 22 Apr 2022 10:22:04 AEST ]]> Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49358 Fri 12 May 2023 12:35:29 AEST ]]> A rodent model of anxiety: The effect of perinatal immune challenges on gastrointestinal inflammation and integrity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36750 Fri 03 Jul 2020 09:05:42 AEST ]]>